Review article

https://doi.org/10.11613/BM.2019.020501

Filaggrin and atopic march

Ivana Čepelak ; Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Slavica Dodig orcid.org/0000-0002-3419-5171 ; Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ivan Pavić orcid.org/0000-0003-2670-2003 ; Department of Pulmonology, Allergology and Immunology, Children’s Hospital Zagreb, Zagreb; School of Medicine University of Zagreb, Croatia

Abstract

There is an increasing number of experimental, genetic and clinical evidence of atopic dermatitis expression as a pre-condition for later development of other atopic diseases such as asthma, food allergy and allergic rhinitis. Atopic dermatitis is a heterogeneous, recurrent childhood disease, also present in the adult age. It is increasingly attributed to systemic features and is characterized by immunological and skin barrier integrity and function dysregulation. To maintain the protective function of the skin barrier, in particular the maintenance of pH, hydration and antimicrobial functions, the filaggrin, among others, plays a significant role. Filaggrin is a multifunctional, histidine-rich, insoluble protein. The lack of filaggrin is associated with various cutaneous (e.g. ichthyosis vulgaris, allergic contact dermatitis)
and non-cutaneous (e.g. diabetes, inflammatory conditions of the gastrointestinal tract) diseases and may be a result of genetic, immunological factors combined with environmental factors.
In this review we summarised (emphasized) recent findings in understanding the role of filaggrin in atopic dermatitis and other diseases, participants in the atopic march.

Keywords

atopic dermatitis; atopic diseases; filaggrin

Hrčak ID:

221073

URI

https://hrcak.srce.hr/221073

Publication date:

15.6.2019.

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