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Biochemia Medica, Vol. 29 No. 2, 2019.

Review article

https://doi.org/10.11613/BM.2019.020503

Croatian Society of Medical Biochemistry and Laboratory Medicine: National recommendations for blood collection, processing, performance and reporting of results for coagulation screening assays prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and D-dimer

Ana Bronić orcid id orcid.org/0000-0001-7383-328X ; Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Desiree Coen Herak orcid id orcid.org/0000-0001-8327-9913 ; Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia
Sandra Margetić ; Department of Clinical Chemistry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Marija Milić orcid id orcid.org/0000-0002-2592-3819 ; Department of Clinical Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia; Faculty of Medicine, University of Osijek, Osijek, Croatia

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Abstract

A modern diagnostic laboratory offers wide spectrum of coagulation assays utilized in the diagnosis and management of patients with haemostatic disorders, preoperative screening and anticoagulation therapy monitoring. The recent survey conducted among Croatian medical biochemistry and transfusion laboratories showed the existence of different practice policies in particular phases of laboratory process during coagulation testing and highlighted areas that need improvement. Lack of assay standardization together with non-harmonized test results between different measurement
methods, can potentially lead to incorrect decisions in patient’s treatment. Consequently, patient safety could be compromised. Therefore, recommended procedures related to preanalytical, analytical and postanalytical phases of prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and D-dimer testing are provided in this review, aiming to help laboratories to generate accurate and reliable test results.

Keywords

blood coagulation tests; haemostasis; standardization; harmonization; guidelines

Hrčak ID:

221075

URI

https://hrcak.srce.hr/221075

Publication date:

15.6.2019.

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