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https://doi.org/10.11613/BM.2019.020902

High-sensitivity cardiac Troponin T delta concentration after repeat pulmonary vein isolation

Ivan Zeljkovic orcid.org/0000-0002-4550-4056 ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland
Sven Knecht ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland
Florian Spies ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland
Tobias Reichlin ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland
Beat Schaer ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland
Stefan Osswald ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland
Michael Kühne ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland
Christian Sticherling ; Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland; Cardiovascular Research Institute Basel, Basel, Switzerland

Abstract

Introduction: Difference between high-sensitivity cardiac troponin T concentrations (hs-cTnT) before and after ablation procedure (delta concentration) reflects the amount of myocardial injury. The aim of the study was to investigate hs-cTnT prognostic power for predicting atrial fibrillation (AF) recurrence after repeat pulmonary vein isolation (PVI) procedure.
Materials and methods: Consecutive patients with paroxysmal AF undergoing repeat PVI using a focal radiofrequency catheter were included in the study. Hs-cTnT was measured before and 18-24 hours after the procedure. Standardized 3, 6 and 12-month follow-up was performed. Cox-regression analysis was used to identify predictors of AF recurrence.
Results: A total of 105 patients undergoing repeat PVI were analysed (24% female, median age 61 years). Median (interquartile range) hs-cTnT delta after repeat PVI was 283 (127 - 489) ng/L. After a median follow-up of 12 months, AF recurred in 24 (23%) patients. A weak linear relationship between the total radiofrequency energy delivery time and delta hs-cTnT was observed (Pearson R2 = 0.31, P = 0.030). Delta Hs-cTnT was not identified as a significant long-term predictor of AF recurrence after repeated PVI (P = 0.920).
Conclusion: This was the first study evaluating the prognostic power of delta hs-cTnT in predicting AF recurrence after repeat PVI. Delta hs-cTnT
does not predict AF recurrence after repeat PVI procedures. Systematic measurement of hs-cTnT after repeat PVI does not add information relevant to outcome.

Keywords

atrial fibrillation; pulmonary vein isolation; high-sensitivity troponin T; repeat procedure; recurrence

Hrčak ID:

221085

URI

https://hrcak.srce.hr/221085

Publication date:

15.6.2019.

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