Original scientific paper

https://doi.org/10.2478/acph-2020-0048

Antiproliferative evaluation of various aminoquinoline derivatives

BRANKA ZORC ; University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia
ZRINKA RAJIĆ ; University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia
IVANA PERKOVIĆ ; University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia

Abstract

Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.

Keywords

primaquine; chloroquine; mefloquine; fumardiamide; antiproliferative activity

Hrčak ID:

221405

URI

https://hrcak.srce.hr/221405

Publication date:

31.12.2019.

Visits: 1.319 *