Meeting abstract
The effect of pentadecapeptide BPC 157 on high-fat diet induced hypertension in rat
Vilim Dretar
; School of Medicine University of Zagreb, Department of Pharmacology
Filip Radevski
; School of Medicine University of Zagreb, Department of Pharmacology
Pavla Peraić
; School of Medicine University of Zagreb, Department of Pharmacology
Josh Fry
; School of Medicine University of Zagreb, Department of Pharmacology
Marko Belamarić
; School of Medicine University of Zagreb, Department of Pharmacology
Marko Antunović
; School of Medicine University of Zagreb, Department of Pharmacology
Ivan Krezić
; School of Medicine University of Zagreb, Department of Pharmacology
Abstract
Hyperlipidaemia, hypercholesterolaemia and hypertriglyceridaemia are known as factors that increas blood pressure and risk of cardiovascular complications. We wanted to examine effects of pentadecapeptide BPC 157 on high-fat diet induced hypertension in rats. 4 Male Winstar Albino rats (240g) 4 months old, were used in this study. 2 rats per each group were fed with fat (white bacon) for 4 weeks. Control group was given water p.o. ad libitum while BPC group was given (10ng/kg) of pentadecapeptide BPC 157 per liter solution p.o. ad libitum. Blood pressure was measured using noninvasive tail cuff method every day for 4 weeks period. Systolic blood pressure increased in both groups but increase in control groups was significantly higher then in BPC 157 threated group (CON day 0. = 158 mmHg, BPC day 0. = 155 mmHg; CON day 25. = 205 mmHg, BPC day 25. = 165 mmHg) .Drop of blood pressure in first few days can be attributed to adapting on the new food that was given to rats. Feeding rats with a high-fat diet is known to produce changes of which one of the consequence is increased blood pressure or hypertension. We proved that pentadecapeptide BPC 157 decreases systolic blood pressure induced by fat diet.
Keywords
BPC 157; high-fat diet; hypertension; rats
Hrčak ID:
221663
URI
Publication date:
9.4.2019.
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