Veterinarska stanica, Vol. 48 No. 5, 2017.
Review article
Contrast media for myelography and possible complications following their application
Mirjana Lazarević Macanović
; Fakultet veterinarske medicine Univerziteta u Beogradu, Srbija
Nikola Radaković
; Fakultet veterinarske medicine Univerziteta u Beogradu, Srbija
Marko Mitrović
; Fakultet veterinarske medicine Univerziteta u Beogradu, Srbija
Abstract
Myelography is the radiological method of examination of the spinal column, and in- volves the application of contrast media into the subarachnoidal space in order to diagnose different pathological conditions. The for- merly used application of oil-based contrast media did not yield consistent, satisfactory re- sults and also carried certain risks. Due to the poor mixing of oil-based contrast agents with cerebrospinal fluid, distribution along the spi- nal canal was uneven, excretion from the body very slow, and their application often caused chronic inflammation. For these reasons, oil- based contrast media have since been replaced with low osmolality, water soluble, non-ionic contrasts. In contemporary radiology, the com- monly used contrast media for myelography are metrizamide, iopamidol and iohexol. Me- trizamide is often used as an isotonic solution
containing 170 mg I/mL, while iopamidol and iohexol are slightly hypertonic, containing ap- proximately 300 mg I/mL. The application of these contrast agents can also produce a wide range of complications in clinical practice, such as neurological exacerbation, hyperaes- thesia, vomiting and apnea. These symptoms are usually a consequence of metrizamide, but may also occur following the administration of iopamidol and iohexsol. In that case, com- plications are mostly transient. Regarding the facts presented, a large number of literature data are outlined in this paper. Moreover, dif- ferent author reports are described regarding the selection of contrast agents, their method of application, and the possible complications that can occur as a result of their usage.
Keywords
contrast media; myelography; dog
Hrčak ID:
222646
URI
Publication date:
15.10.2017.
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