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Acta Dermatovenerologica Croatica, Vol. 27 No. 2, 2019.

Other

Efficacy of omalizumab in patients with chronic spontaneous urticaria and its association with serum IgE levels and eosinophil count

Funda Tamer orcid id orcid.org/0000-0003-4157-5583 ; Ufuk University School of Medicine Department of Dermatology
Fatma Gulru Erdogan orcid id orcid.org/0000-0002-7102-7329 ; Ufuk University School of Medicine Department of Dermatology
Didem Dincer Rota ; Ufuk University School of Medicine Department of Dermatology
Dilsun Yildirim orcid id orcid.org/0000-0002-9144-6790 ; Ufuk University School of Medicine Department of Dermatology
Yesim Akpinar Kara orcid id orcid.org/0000-0003-3834-1858 ; Liv Hospital, Department of Dermatology, Ankara

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Abstract

Chronic spontaneous urticaria can be treated with several drugs such as antihistamines, leukotriene antagonists, cyclosporine, doxepin, hydroxychloroquine, colchicine, and corticosteroids. However, treatment-resistant urticaria significantly reduces quality of life. In recent years, omalizumab has been considered to be an effective treatment option in treatment-resistant cases. We aimed to investigate the clinical efficacy of omalizumab in urticaria and its possible association with serum IgE levels, total eosinophil counts, and basophil percentages. Medical records of 11 patients with chronic spontaneous urticaria treated with omalizumab were reviewed retrospectively. Treatment response, urticaria activity score, serum basophil percentages, eosinophil, and IgE levels evaluated before and at the end of the therapy. Ten patients healed completely with omalizumab. One patient did not respond to therapy. No correlation was observed between serum IgE levels and treatment outcome. However, serum eosinophil levels decreased and basophil percentages increased with omalizumab treatment. Omalizumab is a safe and effective treatment choice in patients with chronic spontaneous urticaria. We suggest that omalizumab may have an effect in the treatment of urticaria through eosinophils.


Keywords

Eosinophil; Immunoglobulin E; Omalizumab; Urticaria

Hrčak ID:

223233

URI

https://hrcak.srce.hr/223233

Publication date:

23.7.2019.

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