Veterinarska stanica, Vol. 50 No. 4, 2019.
Review article
Bone morphogenetic proteins in a rabbit posterolateral spinal fusion model: an overview
Vladimir Farkaš
; Institut Ruđer Bošković, Zagreb, Hrvatska
Lovorka Grgurević
; Medicinski fakultet Sveučilišta u Zagrebu, Hrvatska
Abstract
Lower back pain is an important public health issue worldwide. In recent decades, interventional spine procedures, including spinal fusion surgeries have become common lower back pain therapy, with a 40% increase in the number of spinal fusions performed between 1998 and 2004. Spinal fusion is the surgical technique of joining two vertebrae so that they heal into a single, solid bone. This is done to prevent movement and occurrence of the pain. In order to achieve solid spinal fusion, various osteoinductive materials that stimulate the formation of the new bone are used in the spinal fusion procedure. Autograft is the most preferred osteoinductive material for spine fusion surgeries. However, the use of autografts is often associated with certain limitations and morbidity. Despite all efforts to improve the spinal fusion technique, the reported non-union rate remains high. All these shortcomings of the standard techniques have urged the development of alternative materials and/or supplements for bone grafting, to enhance new bone formation
and facilitate more rapid and robust fusion, with lower morbidity and higher success. Recent efforts in the field have been focused on bone morphogenic proteins (BMP). Of all the bone morphogenetic proteins, BMP2 and BMP7 are most commonly used in animal models of spinal fusion. Both BMP2 and BMP7 have strong osteoinductive properties and their effect on the formation of new bone has been proven in many animal models. In recent years, pre-clinical and clinical trials have also begun for the use of BMP6. As part of enhancing the potential of bone morphogenetic proteins as an alternative for bone grafting, many studies have been carried out involving a “proof of concept” step, feasibility and efficacy trials, testing of various BMP carriers, and complication experiments. This paper provides an overview of the current use of bone morphogenetic proteins in a rabbit model of posterolateral spinal fusion.
Keywords
bone morphogenic proteins; posterolateral spinal fusion; rabbit; animal model
Hrčak ID:
223840
URI
Publication date:
28.7.2019.
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