Original scientific paper
https://doi.org/10.15255/CABEQ.2019.1656
Nonsteroidal Anti-Inflammatory Drug Solid-State Microencapsulation on Green Activated Carbon – Mass Transfer and Host-Guest Interactions
Z. Lyubenova Yaneva
orcid.org/0000-0001-8159-4530
; Chemistry Unit, Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
Abstract
The present study investigated the drug-carrier capacity of green activated carbon derived from fruit stones by steam-gas activation (ACSTA) towards the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen (IBU), and assessed the host-guest interactions and mass transfer mechanism/s of the drug microencapsulation and in vitro release processes. The mass transfer studies outlined that the process of IBU encapsulation on ACSTA microparticles was predominantly controlled by intraparticle solid phase diffusion.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
microencapsulation; ibuprofen; activated carbon; in vitro release
Hrčak ID:
223897
URI
Publication date:
31.7.2019.
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