Original scientific paper

https://doi.org/10.20471/LO.2019.47.01.01

Prediction score for complications after colorectal cancer surgery based on neutrophils/lymphocytes ratio, percentage of immature granulocytes, IG and IT ratios

Ljiljana Mayer ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sanja Langer ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mihaela Gaće ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Pero Hrabač ; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
Milica Šoštarić ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ines Fijan ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zvjezdana Špacir Prskalo ; Department of Medical Biochemistry in Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ana Cvetko ; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Josipa Periša ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ljilja Štefančić ; Departmanet of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ivan Penavić ; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Hrvoje Tomasović ; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Gordana Brozović ; Departmanet of Anaesthesiology, Reanimatology and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Danko Velimir Vrdoljak ; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Abstract

Introduction: The markers of inflammations are a significant predictor of postoperative outcome after colorectal cancer surgery. Along with leukocytes, C-reactive protein (CRP), procalcitonin (PCT) and neutrophil/lymphocyte ratio (NLR) we tried to test the role of immature granulocytes (IG) counts and trends in the postoperative period.
Methods: We recorded matched three patient according to their sex, age, and tumor localization who had an uneventful recovery with three patients who had an anastomotic leak required reoperation. We obtained the IG count with every complete blood count and correlated these with CRP, PCT, NLR. For the best prediction we calculated the potential Zagreb score by adding 1 point for elevated NLR ratio for more than 75%, minimally three consecutively elevated % IG, doubling of immature granulocytes relative value to absolute neutrophils count ratio (IG ratio) and immature granulocytes relative value to leucocytes count ratio (IT ratio) at three consecutive time points.
Results and Conclusion: Potential Zagreb score seems to predict the need for reoperation in time. Herein we introduce its concept, and we plan the retrospective study to test its feasibility and precision.

Keywords

Zagreb score; immature granulocytes; C-reactive protein; neutrophil/leucocyte ratio; colorectal cancer

Hrčak ID:

224356

URI

https://hrcak.srce.hr/224356

Publication date:

6.8.2019.

Article data in other languages: croatian

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