Review article

https://doi.org/10.20471/acc.2019.58.02.21

Expression of the Renin-Angiotensin System Components in Oncologic Diseases

Sergey Dolomatov ; Department of Medical Biology, Medical Academy SI Georgievsky, Crimea Federal University, Simferopol, Russian Federation jurisdiction
Walery Zukow orcid.org/0000-0002-7675-6117 ; Faculty of Earth, Nicolaus Copernicus University, Toruń, Poland
Nikolay Novikov ; A. Tsyb Medical Radiological Research Center, branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Kaluga Region, Russian Federation
Alexandra Markaryan ; Department of Medical Biology, Medical Academy SI Georgievsky, Crimea Federal University, Simferopol, Russian Federation jurisdiction
Elena Eremeeva ; Department of Medical Biology, Medical Academy SI Georgievsky, Crimea Federal University, Simferopol, Russian Federation jurisdiction

Abstract

The literature devoted to changes in the expression of the renin-angiotensin system (RAS) proteins of cancer cells was analyzed. The dynamics of RAS protein expression in malignant tumors and the possible role of epigenetic mechanisms in these processes are briefly reviewed. Through research of the epigenetic mechanisms in cancer, principally new techniques for their correction based on the use of selective regulatory systems of covalent modification of histone proteins (for example, deacetylase inhibitor) and microRNA synthesis technologies have been developed. Literature data show promising pharmacological correction of epigenetic modification of chromatin in the treatment of cancer.

Keywords

Oncology; Ectopic RAS cancer cells; Epigenetic stimulation of RAS in oncology

Hrčak ID:

224611

URI

https://hrcak.srce.hr/224611

Publication date:

1.6.2019.

Article data in other languages: croatian

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