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Acta Dermatovenerologica Croatica, Vol. 27 No. 3, 2019.

Other

Baclofen-induced dyshidrosiform bullous pemphigoid in a paraplegic patient complicated with methicillin-resistant Staphylococcus aureus (mrsa) and urinary infection

Liborija Lugovic Mihic orcid id orcid.org/0000-0001-7494-5742 ; Department of Dermatovenereology University Hospital Center Sestre milosrdnice School of Dental Medicine University of Zagreb
Tomislav Duvancic orcid id orcid.org/0000-0002-6121-3232 ; Department of Dermatovenereology University Hospital Center Sestre milosrdnice School of Dental Medicine University of Zagreb
Ivana Pavic ; Ljudevit Jurak Department of Pathology University Hospital Center Sestre milosrdnice
Ana Gveric Grginic ; Department of Microbiology and Hospital Infections University Hospital Center Sestre milosrdnice
Iva Dediol orcid id orcid.org/0000-0001-7142-3244 ; Department of Dermatovenereology University Hospital Center Sestre milosrdnice
Mirna Šitum

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Abstract

Bullous pemphigoid (BP) is an autoimmune disorder which is usually chronic, with blistering that predominantly affects the skin and occasionally the mucosa, and which includes several different types. One of them is a very rare dyshidrosiform type which is localized on the hands and feet with small or large blisters on the palmoplantar surfaces. BP resulting from a drug reaction is a relatively rare occurrence, and so far more than 50 different medications have been identified as triggers. The aim of this article was to present the case of a paraplegic patient who developed this rare dyshidrosiform type of BP while he was being neurologically treated with baclofen. In spite of therapy with systemic and topical corticosteroids and other measures, successful treatment was achieved only after eliminating baclofen from the patient’s regimen. His general state of health was seriously endangered due to nasal and skin methicillin-resistant Staphylococcus aureus (MRSA), urinary infection, and oral mycosis (soor), and he was at high risk of sepsis and a fatal outcome. Through our efforts, however, we managed to achieve an excellent outcome. According to our knowledge, this was the first case of baclofen-induced dyshidrosiform BP.

 

Keywords

Hrčak ID:

225447

URI

https://hrcak.srce.hr/225447

Publication date:

5.11.2019.

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