Original scientific paper

https://doi.org/10.2478/acph-2020-0022

Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats

LEÓN JESÚS GERMÁN-PONCIANO ; Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México
ABRAHAM PUGA-OLGUÍN orcid.org/0000-0002-5968-0210 ; Programa de Posgrado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México
MARIA DE JESÚS ROVIROSA-HERNÁNDEZ ; Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México
MARIO CABA ; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa 91190, Veracruz, México
ENRIQUE MEZA ; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa 91190, Veracruz, México
JUAN FRANCISCO RODRÍGUEZ-LANDA orcid.org/0000-0001-5837-103X ; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México; Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa 91000, Veracruz, México

Abstract

The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 umol kg–1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxiety, in male Wistar rats. These effects were compared with the clinically effective anxiolytic diazepam 7 umol kg–1. The results showed that acute, but not chronic treatment, with 4 umol kg-1 chrysin exerted anxiolytic- and antidepressant-like effects, andwith these effects were being similar to that of diazepam. Also, none of the above above-mentioned treatments did alter Fos immunoreactivity in the LSN, but a tendency towards athe reduction of this variable was detected with chrysin 4 umol kg–1 and diazepam 7 umol kg–1. Altogether, results suggest that chrysin exerts anxiolytic-like effects, but however, it can produce pharmacological tolerance after repeated use, similar to benzodiazepines.

Keywords

chrysin; anxiolytic; elevated plus maze; Fos protein; lateral septal nucleus

Hrčak ID:

225574

URI

https://hrcak.srce.hr/225574

Publication date:

30.9.2020.

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