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Original scientific paper

Treatment of Total Limbal Stem Cell Deficiency With Autologous Ex Vivo Cultivated Limbal Epithelial Stem Cell Graft

Iva Dekaris ; Special Eye Hospital ‘Svjetlost’, Zagreb Croatia
Mirna Tominac-Trcin ; Tissue Bank, University Department of Traumatology, University Hospital Centre «Sestre Milosrdnice», Zagreb, Croatia
Doria Gabrić ; Special Eye Hospital ‘Svjetlost’, Zagreb Croatia

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Limbal epithelial stem cell (LSC) deficiency is severe disease of the anterior eye surface, causing corneal opacification and significant vision loss in the affected patients. Treatment of such patients by corneal graft is ineffective due to the fact that corneal donor tissue cannot survive in the eye without LSC. One of possible treatment options is to provide LSC from the other, unaffected eye, and to perform corneal graft later on, as a second procedure. In this paper, we have evaluated the visual outcome and clinical improvement in three eyes receiving ex vivo cultivated limbal epithelial stem cell graft to treat their limbal stem cell deficiency (LSCD) caused by corneal burn. We aimed at determining whether this treatment alone might provide sufficient visual improvement to avoid corneal grafting as a second surgery.


corneal burn; limbal stem cell deficiency; ex vivo cultivation of limbal stem cells; corneal transplantation

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