Meeting abstract

https://doi.org/10.15836/ccar2019.263

Mineralocorticoid Receptor Antagonist Eplerenone in Cardiovascular Disease

Ivo Planinc orcid.org/0000-0003-0561-6704

Abstract

Aldosterone and eplerenone are mineralocorticoid receptor antagonists with one of the main roles in the treatment of heart failure, as demonstrated by large randomized controlled trials. Effects on patient outcomes are the result of blocking the renin-angiotensin-aldosterone system, which improves cardiac remodeling. Besides heart failure, mineralocorticoid receptor antagonists are used in treatment of patients with resistant arterial hypertension. This review focuses on the pharmacokinetics, pharmacodynamics, clinical effects, and safety profile of eplerenone.

Keywords

mineralocorticoid receptor antagonists; eplerenone; heart failure; arterial hypertension; hyperkalemia

Hrčak ID:

226723

URI

https://hrcak.srce.hr/226723

Publication date:

15.10.2019.

Article data in other languages: croatian

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