Professional paper

Acute Angioedema and Urticaria Associated with Herpes Simplex Infection

Pornpan Youngnak-Piboonratanakit ; Faculty of Dentistry, Chulalongkorn University, Bangkok,Thailand
Yuzo Takahashi ; Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Yusuke Nakajima ; Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ken Omura ; Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Abstract

We report a case of acute angioedema and urticaria, which is possibly induced by herpes simplex virus infection. A Japanese 58-year-old male patient presented urticaria including cutaneous erythematous rashes at extremities and trunk. He also developed angioedema which was characterized by swelling of lips, tongue, face, and periorbital tissue with difficulty in breathing, speaking, and fullness in throat. Six days later, crusted ulcers were detected on lower lip. Complete blood studies and biochemical screening examination, antibody titers for viral infections, urinalysis and scratch test for drug hypersensitivity have been investigated. Interestingly, serum complement fixation antibody titer for HSV howed high titer at 1:32. Accompanied by oral ulcerations, he was diagnosed as herpes labialis. The patient was admitted and treated intravenously with antihistamine, penicillin, and corticosteroid. After 3 days of treatment, his symptoms significantly improved. From 3-year followup, he had not developed angioedema and urticaria. This letter shows clinical pictures, treatment and possibility of the relation of angioedema and urticaria with herpes simplex virus infection. However, one should also consider the possibility of coincidence of herpes simplex virus infection.

Keywords

Angioedema; Simplex virus; Urticaria; Herpes Labialis

Hrčak ID:

21256

URI

https://hrcak.srce.hr/21256

Publication date:

15.3.2008.

Article data in other languages: croatian

Visits: 7.355 *