Original scientific paper
THE EFFECT OF VITAMIN D ON PREGNANCY AND BIRTH OUTCOMES IN WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE
TATIANA S. FADEEVA
; Tula Medical University, Department of Obstetrics and Gynecology, Tula, Russia
Abstract
Background: the relevance of undifferentiated connective tissue disease (UCTD) in obstetric and gynecological practice is associated with a high (up to 80%) prevalence of pathology among women of reproductive age and the risk of developing pathology in the pregnant woman and the newborn. Objective: to study the effect of magnesium and vitamin D in the complex therapy of pregnant women with UCTD on the course of pregnancy, childbirth, the state of women in labor and newborns. Methods: 142 women with manifestations of UCTD were analyzed during pregnancy. Depending on the treatment regimen, the patients were divided into groups: pregnant groups 1 (n = 87) received in continuous mode “Magne-B6” - 4 tablets / day (192 mg), groups 2 (n = 55) and additionally “Aquadetrim” - 1000 IU/ day. The survey was conducted according to a single scheme. Results: it was found that taking magnesium and vitamin D drugs compensates for their deficiency in the pregnant woman's body with UCTD and reduces the risk of preeclampsia (p = 0.031), fetal growth retardation syndrome (p = 0.048), contributes to a more rapid physiological adaptation of the newborn in the early postpartum period (p <0.05), its lesser morphofunctional immaturity (p = 0.030) and reduces manifestations of conjugative jaundice (p = 0.019). Conclusions: taking magnesium and vitamin D compensates for their deficiency in the body of a pregnant woman with UCTD, which reduces the risk of complications from the woman and the newborn.
Keywords
undifferentiated connective tissue disease; vitamin D; magnesium; pregnancy; newborns; obstetric and perinatal complications; preeclampsia
Hrčak ID:
230809
URI
Publication date:
5.12.2019.
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