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Acta clinica Croatica, Vol. 58. No. Supplement 2, 2019.

Professional paper

https://doi.org/10.20471/acc.2019.58.s2.04

Surgical Treatment of High-Risk Prostatic Carcinoma and Oligometastatic Disease

Ivica Mokos orcid id orcid.org/0000-0003-0564-1803 ; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Ahmad El Saleh ; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Tomislav Kuliš ; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Marija Topalović Grković ; Department of Anesthesiology, University Hospital Center Zagreb, Zagreb, Croatia
Iva Bačak Kocman ; Department of Anesthesiology, University Hospital Center Zagreb, Zagreb, Croatia
Željko Kaštelan ; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia

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Abstract

Prostate cancer is responsible for the largest number of cancer-related deaths in male population in many countries of the world. Aggressive forms of the disease are associated with an increased risk of local recurrence and death. Treatment of high-risk local prostate cancer most commonly involves radical prostatectomy (RP) or external beam radiation therapy (EBRT ) combined with androgen deprivation therapy (ADT ) with or without the addition of brachytherapy (BT). The use of surgery for high risk prostatic carcinoma (HR PC) is on the rise, because of its advantages including the possibility of cure with surgery alone without the risk of toxicities from prolonged ADT, accurate staging, and avoiding the influence of PSA originating from benign prostatic hyperplasia on future therapy. Oligometastatic prostate cancer may be considered as the last border of possibly curable disease. Radical prostatectomy in oligometastatic prostate cancer can significantly decrease the risk of local complications but only multimodal approach in selected group of patients may offer opportunities to eradicate tumor or delay its progression. Surgery for oligometastatic disease most commonly targets lymphatic disease with salvage pelvic lymph node dissection, whereas it rarely targets distant metastases. Further prospective, randomized studies are necessary to define the role and value of therapies in oligometastatic prostate cancer.

Keywords

Prostatic Neoplasms; Urologic Surgical Procedures; Lymph Node Excision; Metastasectomy

Hrčak ID:

233416

URI

https://hrcak.srce.hr/233416

Publication date:

1.11.2019.

Article data in other languages: croatian

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