Original scientific paper

https://doi.org/10.24869/psyd.2019.162

INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY

Martina Rojnic Kuzman ; Zagreb University Hospital Centre, Zagreb, Croatia
Porin Makaric ; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Dina Bosnjak Kuharic ; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Ivana Kekin ; Zagreb University Hospital Centre, Zagreb, Croatia
Linda Rossini Gajsak ; Neuropsychiatric Hospital “Dr. Ivan Barbot”, Popovaca, Croatia
Marina Boban ; Zagreb University Hospital Centre, Zagreb, Croatia
Nada Bozina ; Zagreb University Hospital Centre, Zagreb, Croatia
Tamara Bozina ; Zagreb School of medicine, Zagreb, Croatia
Mirela Celic Ruzic ; Neuropsychiatric Hospital “Dr. Ivan Barbot”, Popovaca, Croatia
Sanja Darmopil ; Zagreb School of medicine, Zagreb, Croatia
Igor Filipcic ; Neuropsychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Lana Ganoci ; Zagreb University Hospital Centre, Zagreb, Croatia
Ana Hladnik ; Zagreb School of medicine, Zagreb, Croatia
Zoran Madzarac ; Zagreb University Hospital Centre, Zagreb, Croatia
Branko Malojcic ; Zagreb University Hospital Centre, Zagreb, Croatia
Alma Mihaljevic Peles ; Zagreb University Hospital Centre, Zagreb, Croatia
Daniel J. Mueller ; Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada and Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Drazenka Ostojic ; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Zdravko Petanjek ; Zagreb School of medicine, Zagreb, Croatia
Ratimir Petrovic ; Zagreb University Hospital Centre, Zagreb, Croatia
Zeljka Vogrinc ; Zagreb University Hospital Centre, Zagreb, Croatia
Aleksandar Savic ; University Psychiatric Hospital Vrapce, Zagreb, Croatia
Ante Silic ; Department of Psychiatry, Clinical Hospital Centre “Sestre Milosrdnice“, Zagreb, Croatia
Marina Sagud ; Zagreb University Hospital Centre, Zagreb, Croatia
Maja Zivkovic ; Zagreb University Hospital Centre, Zagreb, Croatia
Zarko Bajic ; Biometrika Healthcare Research, Zagreb, Croatia

Abstract

In this project, we recruited a sample of 150 patients with first episode of psychosis with schizophrenia features (FEP) and 100 healthy controls. We assessed the differences between these two groups, as well as the changes between the acute phase of illness and subsequent remission among patients over 18-month longitudinal follow-up. The assessments were divided into four work packages (WP): WP1- psychopathological status, neurocognitive functioning and emotional recognition; WP2- stress response measured by saliva cortisol during a stress paradigm; cerebral blood perfusion in the resting state (with single photon emission computed tomography (SPECT) and during activation paradigm (with Transcranial Ultrasonography Doppler (TCD); WP3-post mortem analysis in histologically prepared human cortical tissue of post mortem samples of subjects with schizophrenia in the region that synaptic alteration was suggested by WP1 and WP2; WP4- pharmacogenetic analysis (single gene polymorphisms and genome wide association study (GWAS). We expect that the analysis of these data will identify a set of markers that differentiate healthy controls from patients with FEP, and serve as an additional diagnostic tool in the first episode of psychosis, and prediction tool which can be then used to help tailoring individualized treatment options. In this paper, we describe the project protocol including aims and methods and provide a brief description of planned post mortem studies and pharmacogenetic analysis.

Keywords

schizophrenia; first episode psychosis; biological markers; neurocognition; TCD; SPECT; stress; cortisole

Hrčak ID:

235105

URI

https://hrcak.srce.hr/235105

Publication date:

9.7.2019.

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