Original scientific paper

https://doi.org/10.24869/psyd.2019.211

ASSOCIATION ANALYSIS OF MAOA AND SLC6A4 GENE VARIATION IN SOUTH EAST EUROPEAN WAR RELATED POSTTRAUMATIC STRESS DISORDER

Nermina Kravić orcid.org/0000-0002-0562-5806 ; Department of Psychiatry, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Emina Šabić Džananović ; Department of Psychiatry, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Mirnesa Muminović Umihanić ; Community Health Centre Živinice, Živinice, Bosnia and Herzegovina
Alma Džubur Kulenović ; Department of Psychiatry, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Osman Sinanović ; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Miro Jakovljević ; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Dragan Babić ; Department of Psychiatry, University Clinical Centre of Mostar, Mostar, Bosnia and Herzegovina
Abdulah Kučukalić ; Department of Psychiatry, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Ferid Agani ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Sabina Kučukalić ; Department of Psychiatry, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Alma Bravo Mehmedbašić ; Department of Psychiatry, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Aferdita Goci Uka ; Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo
Shpend Haxhibeqiri ; Institute of Kosovo Forensic Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Valdete Haxhibeqiri ; Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo
Blerina Hoxha ; Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo
Branka Aukst Margetić ; Department of Psychiatry, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia
Nenad Jakšić ; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Ana Cima Franc ; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Duško Rudan ; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Marko Pavlović ; Department of Psychiatry, University Clinical Centre of Mostar, Mostar, Bosnia and Herzegovina
Romana Babić ; Department of Psychiatry, University Clinical Centre of Mostar, Mostar, Bosnia and Herzegovina
Elma Ferić Bojić ; Department of Genetics and Bioengeneering, International Burch University, Sarajevo, Bosnia and Herzegovina
Damir Marjanović ; Department of Genetics and Bioengeneering, International Burch University, Sarajevo, Bosnia and Herzegovina
Nada Božina ; Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia
Christiane Ziegler ; Department of Psychiatry, Psychosomatics and Psychotherapy, Centre of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Christiane Wolf ; Department of Psychiatry, Psychosomatics and Psychotherapy, Centre of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Bodo Warrings ; Department of Psychiatry, Psychosomatics and Psychotherapy, Centre of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Katharina Domschke ; Department of Psychiatry, Psychosomatics and Psychotherapy, Centre of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Jürgen Deckert
Esmina Avdibegović ; Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia

Abstract

Background: The aim of this study is to investigate the association of gene variations of the monoamine oxidase A (MAOA) and the serotonin transporter solute carrier family 6 member 4 (SLC6A4) gene with posttraumatic stress disorder (PTSD) severity and coping strategies in patients with war related PTSD.
Subjects and methods: The study included 747 individuals who had experienced war trauma in the South Eastern Europe conflicts between 1991 and 1999. Genotyping of the MAOA VNTR and SLC6A4 tandem repeat polymorphism in combination with rs25531 was done in 719 participants: 232 females and 487 males. Among them, 369 have had current or lifetime PTSD and 350 have had no PTSD symptoms. For psychometric approach we used the Clinician Administrated PTSD Scale (CAPS), the Brief Symptom Inventory (BSI), the adapted Hoffman Lazarus Coping scale and a basic socio-demographic data questionnaire. Results: There were no significant intergroup (PTSD versus non PTSD) differences in the genotype distribution of MAOA and SLC6A4 gene polymorphisms. The primary finding of our study was that the MAOA short allele (MAOA-S) was nominally significantly associated with the severity of PTSD symptoms in the total subgroup of participants with lifetime PTSD; males for symptoms of hyperarrousal and females with symptoms of re-experience and hyperarousal. In our research the male subsample with current PTSD and MAOA-S genotype had nominally significantly higher scores for some positive coping strategies compared to those carrying the long allele genotype (MAOA-L). There was no significant association between the severity of PTSD symptoms, BSI phenotype, coping scores and the SLC6A4 genotype.
Conclusion: The present results support the notion that MAOA VNTR gene variation modulates development and recovery of posttraumatic stress disorder in a war traumatised population, but did not support a connection between SLC6A4 gene variations and war related PTSD.

Keywords

MAOA; SLC6A4; posttraumatic stress disorder; single nucleotide; polymorphisms; neurogenetics

Hrčak ID:

235133

URI

https://hrcak.srce.hr/235133

Publication date:

9.7.2019.

Visits: 1.193 *