Original scientific paper

https://doi.org/10.24869/psyd.2019.256

ROLE OF THE ALLELIC VARIATION IN THE 5-HYDROXYTRYPTAMINE RECEPTOR 1A (HTR1A) AND THE TRYPTOPHAN HYDROXYLASE 2 (TPH2) GENES IN THE DEVELOPMENT OF PTSD

Afërdita Goçi Uka ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Ferid Agani ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Afrim Blyta ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Blerina Hoxha ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Shpend Haxhibeqiri ; Institute of Kosovo Forensic Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Valdete Haxhibeqiri ; Department of Medical Biochemistry, University Clinical Center of Kosovo, Prishtina, Kosovo
Emina Sabic Dzananovic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Sabina Kucukalic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Alma Bravo Mehmedbasic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Abdulah Kucukalic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Alma Dzubur-Kulenovic ; Department of Psychiatry, University Clinical Center, Sarajevo, Bosnia and Herzegovina
Elma Feric Bojic ; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina
Damir Marjanovic ; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina; Institute for Anthropological Researches, Zagreb, Croatia
Nermina Kravic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Esmina Avdibegovic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Mirnesa Muminovic Umihanic ; Community Health Center Zivinice, Zivinice, Bosnia and Herzegovina
Nenad Jaksic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Ana Cima Franc ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Dusko Rudan ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Miro Jakovljevic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Romana Babic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Marko Pavlovic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Dragan Babic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Branka Aukst Margetic ; Department of Psychiatry, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Nada Bozina ; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
Osman Sinanovic ; Department of Neurology, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina
Christiane Ziegler ; Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Bodo Warrings ; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Katharina Domschke ; Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
Jürgen Deckert ; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Christiane Wolf ; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany

Abstract

Background: Post-traumatic stress disorder (PTSD) is a stress related disorder which can occur in an individual after exposure to a traumatic event. It most commonly co-occurs with depression. The two disorders share not only overlapping symptoms, but also genetic diathesis. The aim of this study was to investigate the potential role of single nucleotide polymorphisms (SNPs) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1A (HTR1A) and tryptophan hydroxylase 2 (TPH2) in the pathogenesis of PTSD and comorbid psychopathology.
Subjects and methods: 719 (487 males, 232 females) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Herzegovina, Kosovo and Croatia were included in the study. The Sociodemographic questionnaire, Mini International Neuropsychiatric Interview (M.I.N.I.), Clinician Administered PTSD Scale (CAPS) and Brief Symptom Inventory (BSI) were used to collect clinical data. The SNPs rs6295 (HTR1A), rs11178997 and rs1386494 (TPH2) were investigated for their association with PTSD and comorbid psychopathology.
Results: A nominal significant association was found between the BSI total score in Lifetime PTSD with the SNP rs6295 of the HTR1A gene. The best result was seen in the dominant model (P=0.018), with the minor allele (C) being the risk allele. Several BSI subscores were also associated with the minor (C) allele in Lifetime PTSD. No association was found for the TPH2 SNPs rs11178997 and rs1386494 in relation to PTSD or comorbid psychopathology.
Conclusions: Our findings suggest that rs6295 in the HTR1A gene may contribute to the psychopathology of PTSD.

Keywords

PTSD; single nucleotide polymorphisms; 5-hydroxytryptamine receptor 1A; tryptophan hydroxylase2

Hrčak ID:

235167

URI

https://hrcak.srce.hr/235167

Publication date:

9.7.2019.

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