Veterinary Archives, Vol. 90 No. 1, 2020.
Short communication, Note
https://doi.org/10.24099/vet.arhiv.0218
Effects of dietary acetaminophen and vitamin C supplements on stress and inflammatory responses in Korean native cattle vaccinated with foot-and-mouth disease vaccine - a short communication
Eun-Kee Park
; Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan, South Korea
Song-Ee Son
; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea
Suk Kim
; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea
Hu-Jang Lee
; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea
Abstract
This study evaluated the effect of a combination of acetaminophen and vitamin C (CAV) for reduction of stress and inflammatory responses in calves vaccinated with foot-and-mouth disease (FMD) vaccine. Twenty-five calves were divided into five groups of 5 calves. The negative control was non-vaccination and non-drug treatment. The positive control, and experimental groups I, II and III were vaccinated with FMD vaccine and treated with CAV at concentrations of 0.0, 0.5, 1.0 and 2.0 kg/ton feed, respectively, for five consecutive days post-vaccination. On day 5 post-treatment, serum cortisols and tumor necrosis factor-α (TNF-α) were significantly decreased in all treatment groups compared with the positive control (P<0.05). However, there was no significant difference in serum cortisol and TNF-α levels between experimental groups I and II and the negative control. The results from this study suggest that CAV may be a useful drug for control of the stress and inflammation caused by FMD vaccination in calves.
Keywords
foot and mouth disease vaccination; serum cortisol; serum TNF-α; acetaminophen; vitamin C; cattle
Hrčak ID:
235743
URI
Publication date:
16.3.2020.
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