Medica Jadertina, Vol. 50 No. 1, 2020.
Professional paper
Clinicopathological characteristic and prognostic factors for FIGO stage 1A2-1B2 of cervical cancer
Daren Lučinger
; University of Zagreb, School of medicine
Luka Matak
; General hospital Zadar, Department of obstetrics and gynecology
Mislav Mikuš
; Department of obstetrics and gynecology UHC Zagreb
Ante Ćorušić
; Department of obstetrics and gynecology UHC Zagreb
Pavao Planinić
; Department of obstetrics and gynecology UHC Zagreb
Goran Vujić
; Department of Obstetrics and Gynecology UHC Zagreb
Abstract
Introduction: Cervical cancer is one of the most common malignant tumors of the female reproductive system in women between 15-35 years of age. It takes third place in the frequency of all reproductive system cancers in Croatia. The aim of the present study was to analyze prognostic factors influencing on reccurence to improve therapeutic management.
Materials and Methods: We reviewed medical records and pathological materials obtained from 61 patients with stage IA2-IB2 between 2003 and 2013. The comparison of women with and without recurrence showed statistical significance in certain factors; age when diagnosed, size of tumor, depth of stromal invasion, lymph vascular space invasion, infiltration of the uterine isthmus and lymph node metastases.
Results: Median age at diagnosis was 46 years. Lymph-vascular space invasion (LVSI) was present in 22 (36.1%) with cervical isthmus involvement in 18 (29.5%) patients. Tumor recurrence within observation interval was present in 6 (9.8%) patients. Median time of reccurrence was 24 (range 14-48) months. In univariate statistical analysis lymph-vascular space invasion (P=0.011), cervical isthmus involvement (P=0.002) and positive lymph nodes (P=0.005) were significant parameters for occurrence of recidive while in multivariate statistical analysis cervical isthmus involvement (P=0.036) remained as only independent risk factor for recidive occurrence.
Conclusion: Cervical isthmus involvement could be of prognostic importance especially in the early stage of cervical cancer when we might decide in adding radiotherapy and concomitant chemotherapy to improve overall survival and lower recurrence rate.
Keywords
cervical cancer; prognostic factors; recurrence rate
Hrčak ID:
236692
URI
Publication date:
9.4.2020.
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