Original scientific paper
https://doi.org/10.2478/10004-1254-59-2008-1835
Effects of Progesterone on Benzene Toxicity in Rats
Yeshvandra Verma
; Ch. Charan Singh University, Meerut, India
Suresh Vir Singh Rana
; Ch. Charan Singh University, Meerut, India
Abstract
Benzene is a frequently used industrial solvent. Its toxic manifestations could be modified by sex hormones, but mechanisms of their action are poorly understood. We have examined the influence of progesterone on lipid peroxidation (malondialdehyde), reduced glutathione (GSH), and cytochrome P450 2E1 (CYP2E1) in the liver and kidneys of female rats. Progesterone applied to benzene-treated rats inhibited the formation of reactive oxygen species (ROS), but in ovariectomised benzene-treated rats it significantly increased GSH in the liver. No improvement in CYP2E1 activity was observed in progesterone treated rats. Our results evidence that progesterone changes benzene toxicity (generation of ROS, oxidative stress). However, the probable antioxidative effect of progesterone needs to be confirmed by further studies.
Keywords
CYP2E1; glutathione; lipid peroxidation; kidney; liver; oxidative stress; phase-I enzymes; reactive oxygen species
Hrčak ID:
21858
URI
Publication date:
21.3.2008.
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