Professional paper
https://doi.org/10.21860/medflum2020_237304
Clinical and biochemical features of obesity in patients with schizophrenia
Sergej Nadalin
orcid.org/0000-0002-1601-9094
; Zavod za medicinsku biologiju i genetiku, Medicinski fakultet Sveučilišta u Rijeci, Hrvatska
Jelena Rebić
; Klinika za psihijatriju, Klinički bolnički centar Rijeka, Hrvatska
Klementina Ružić
; Klinika za psihijatriju, Klinički bolnički centar Rijeka, Hrvatska
Kristina Ilinović
; Fakultet zdravstvenih studija Sveučilišta u Rijeci, Hrvatska
Vesna Šendula Jengić
; Psihijatrijska bolnica Rab, Hrvatska
Vjekoslav Peitl
; Klinika za psihijatriju, Klinički bolnički centar Sestre milosrdnice i Hrvatsko katoličko sveučilište, Hrvatska
Dalibor Karlović
; Klinika za psihijatriju, Klinički bolnički centar Sestre milosrdnice i Hrvatsko katoličko sveučilište, Hrvatska
Alena Buretić-Tomljanović
; Zavod za medicinsku biologiju i genetiku, Medicinski fakultet Sveučilišta u Rijeci, Hrvatska
Abstract
Aim: We investigated the association between obesity and clinical characteristics of schizophrenia, such as age, illness duration, age of illness onset, nicotine dependence and clinical psychopathology measured via Positive and Negative Syndrome Scale scores. We also tested whether obesity contributes to biochemical parameters: plasma total cholesterol, LDL cholesterol (low density lipoprotein cholesterol), HDL cholesterol (high density lipoprotein cholesterol), and triglyceride and glucose levels. Patients and methods: Our study group consisted of 142 chronically ill patients with schizophrenia. Patients were classified as obese with body mass index (BMI) values > 30, and non-obese, those who were overweight (BMI: 25 – 30), or those having a normal body weight (BMI: < 25). Results: We did not find statistically significant associations between obesity and clinical characteristics (P > 0.05). Plasma total cholesterol and LDL concentrations were significantly higher in obese females compared to non-obese females, and significantly greater plasma triglyceride values were observed among obese patients of both genders compared to non-obese (P < 0.05). However, only the illness duration significantly predicted triglyceride concentration in females, whereas the influence of obesity on triglyceride levels did not reach significance (P > 0.05). The obesity accounts for approximately 8.3 % variability of triglyceride values in males and 9.6 % and 13.8 % of total cholesterol and LDL cholesterol variability in females. Conclusion: The obesity significantly contributes only to biochemical parameters in patients with schizophrenia. In males, it determines triglyceride values, whereas in females, it underlies total cholesterol and LDL cholesterol levels, accounting for approximately 8.3 – 13.8 % of their variability.
Keywords
body mass index; obesity; schizophrenia
Hrčak ID:
237304
URI
Publication date:
1.6.2020.
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