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Croatian Medical Journal, Vol. 59 No. 4, 2018.

Original scientific paper

https://doi.org/10.3325/cmj.2018.59.149

Prognostic value of lactates in relation to gas analysis and acid-base status in patients with pulmonary embolism

Kristina Galić ; Department for Lung Diseases, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Danijel Pravdić ; Department of Physiology, University of Mostar School ofMedicine, Mostar, Bosnia and Herzegovina
Zrinko Prskalo ; Department for Internal Diseases, University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina
Suzana Kukulj ; Department for Internal Diseases, University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina
Boris Starčević ; Department for Internal Diseases, University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina
Mladenka Vukojević ; University of Mostar School of Medicine, Mostar, Bosnia and Herzegovina

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page 149-155

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Abstract

Aim To assess the prognostic value of lactate level for mortality
in patients with pulmonary embolism (PE) and Pulmonary
Embolism Severity Index (PESI) I-III and its independence
of gas-analysis parameters and acid-base status.
Methods This prospective observational study was conducted
at the University Clinical Hospital Mostar from 2013
to 2017. On the first day after PE diagnosis, 1.5 mL of arterial
blood was collected from 103 patients with PE. Partial
pressure of oxygen in arterial blood, partial pressure of carbon
dioxide in arterial blood, blood pH value, concentration
of bicarbonates in arterial blood (HCO3-), base deficit,
and oxygen saturation were analyzed. Lactate levels were
assessed using blood samples taken from the cubital vein.
Logistic regression analysis was used to assess the predictive
value of gas-analysis variables, lactate level, PESI score,
age, and sex for in-hospital death due to PE.
Results The mortality in the group of PE patients was
19.1% (18 of 103 patients). Lactate level was an independent
predictor of mortality (P = 0.002, odds ratio 0.06). HCO3-
was also found to be a significant predictor (P = 0.022, odds
ratio 2.4). Lactates were independent of other variables.
Other gas-analysis parameters were not significant predictors
of mortality.
Conclusion In PE patients at low-intermediate risk of mortality
(PESI I-III), lactate level was associated with a shortterm
mortality, independently of other gas-analytic parameters.

Keywords

Hrčak ID:

237481

URI

https://hrcak.srce.hr/237481

Publication date:

15.8.2018.

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