Professional paper

https://doi.org/10.37797/ig.39.1.5

Hepatitis E Induced "Acute-On-Chronic" Liver Failure - Do We Transplant or Not?

Petra Dinjar Kujundžić ; Clinical Hospital Merkur, Zagreb, Croatia
Jadranka Pavičić Šarić ; Clinical Hospital Merkur, Zagreb, Croatia
Ljiljana Betica Radić ; General Hospital Dubrovnik, Dubrovnik, Croatia
Adriana Vince ; University Hospital for Infectious Diseases
Ana Ostojić ; Clinical Hospital Merkur, Zagreb, Croatia
Ivan-Budimir Bekan ; Clinical Hospital Merkur, Zagreb, Croatia
Anna Mrzljak ; Clinical Hospital Merkur, Zagreb, Croatia; School of Medicine, University of Zagreb

Abstract

Hepatitis E virus is a pathogen of worldwide significance. In developed countries, foodborne transmission of zoonotic genotypes is the most common route of infection. Transfusion transmitted infection is also an important source of infection, particularly in immunocompromised population. In most cases, HEV infection is asymptomatic or presents as an acute self-limiting hepatitis. Rarely it leads to fulminant hepatitis or "acute-on- chronic" liver failure in people with pre-existing chronic liver diseases. The aim of this report is to present the first documented case of HEV-related "acute-on-chronic" liver failure in Croatia in a patient with chronic liver disease listed for liver transplantation. Due to increasing incidence in industrialised countries, HEV infection should always be considered in the differential diagnosis of acute hepatitis and in patients with unexplained worsening of chronic liver disease.

Keywords

hepatitis E; acute-on-chronic; liver transplantation

Hrčak ID:

237577

URI

https://hrcak.srce.hr/237577

Publication date:

30.4.2020.

Article data in other languages: croatian

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