Original scientific paper

https://doi.org/10.2478/v10007-008-0007-2

In vitro antitumor and antiviral activities of new benzothiazole and 1,3,4-oxadiazole-2-thione derivatives

TASHFEEN AKHTAR ; Department of Chemistry, Quaid-I-Azam University, Islamabad-45320, Pakistan
SHAHID HAMEED orcid.org/0000-0002-1195-1659 ; Department of Chemistry, Quaid-I-Azam University, Islamabad-45320, Pakistan
NAJIM A. AL-MASOUDI ; Fachbereich Chemie, Universität Konstanz, Postfach 5560, D-78457 Konstanz, Germany (formerly)
ROBERTA LODDO ; Department of Biomedical Sciences and Technologies, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (CA), Italy
PAOLO LA COLLA ; Department of Biomedical Sciences and Technologies, University of Cagliari, Cittadella Universitaria, 09042 Monserrato (CA), Italy

Abstract

A series of new benzothiazole derivatives 6a-h have been synthesized, in five steps, from substituted phenols via the 1,3,4-oxadiazole-2-thiones 5a-h. The in vitro antitumor activity of the compounds obtained was investigated and the benzothiazol derivatives 6d and 6e showed high effects on leukaemia cell lines CCRF-CEM (CC50 = 12 ± 2 µmol L1, 8 ± 1 µmol L1, respectively). These compounds are leading candidates for further development. The title compounds were tested against representatives of several virus families containing single stranded RNA genomes, either positive-sense (ssRNA+), or negative-sense (RNA-), and against double-stranded RNA genomes (dsRNA), as well as some Flaviviridae viruses.

Keywords

1,3,4-oxathiazoles; substituted benzothiazoles; antitumor activity; antiviral activity

Hrčak ID:

21939

URI

https://hrcak.srce.hr/21939

Publication date:

1.6.2008.

Article data in other languages: croatian

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