Original scientific paper

Gatifloxacin pharmacokinetics in buffalo calves after single intramuscular administration

Mukesh Raipuria ; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Vinod Kumar Dumka ; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Harpal Singh Sandhu ; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India
Data Ram ; Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University,Ludhiana, India

Abstract

The pharmacokinetics and in vivo plasma protein binding of gatifloxacin after a single intramuscular injection of 4 mg/kg were studied in buffalo calves. The minimum therapeutic concentration of drug was maintained in plasma from 1 min to 12 h. Gatifloxacin was rapidly absorbed from the extravascular site of injection, as evident from the high value of absorption rate constant (4.91 ± 0.22 /h) and attained a Cmax of 2.98 ± 0.08 μg/mL at 1h. The area under the plasma concentration-time curve and apparent volume of distribution were 10.8 ± 0.64 μg/mL/h and 3.2 ± 0.08 L/kg, respectively. Elimination half-life and total body clearance were 7.45 ± 0.55 h and 301.5 ± 34.4 mL/kg/h, respectively. Cmax/MIC ratio was 14.9 ± 0.3 and systemic bioavailability was 79.7 ± 3.35 per cent. Gatifloxacin was bound to plasma proteins of buffalo calves to the extent of 25.0 ± 1.05 per cent. A suitable intramuscular dosage regimen of gatifloxacin in buffalo calves would be 6.0 mg/kg followed by 5.3 mg/kg at 24 h intervals.

Keywords

buffalo calves; dosage; gatifloxacin; pharmacokinetics

Hrčak ID:

21945

URI

https://hrcak.srce.hr/21945

Publication date:

20.12.2006.

Article data in other languages: croatian

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