Original scientific paper
THE VALUE OF CASPASE 3 IN DIFFERENTIATING RENAL ONCOCYTOMA FROM CHROMOPHOBE RENAL CELL CARCINOMA
FRAN ČAKAR
; University of Zagreb, School of Medicine, Department of Pathology, Zagreb, Croatia
TIHANA REGOVIĆ DŽOMBETA
orcid.org/0000-0002-8858-3524
; University of Zagreb, School of Medicine, Department of Pathology and Sestre milosrdnice University Hospital Centre, Ljudevit Jurak Department of Pathology and Cytology, Zagreb, Croatia
Abstract
Aim: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC) are epithelial neoplasms of the kidney with overlapping histologic features, making their differential diagnosis one of the pitfalls in renal pathology. The aim of this study was to assess the level of caspase 3 expression in RO and ChRCC, in order to investigate its potential value in their differentiation. Methods: The study included 24 RO cases and 24 ChRCC cases, taken from the archives of Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Centre Zagreb. The results of immunohistochemical analysis were determined semiquantitatively using immunohistochemical staining index (ISI). Statistical analysis was done using Mann-Whitney U test. Results: All samples showed positive immunohistochemical reaction for caspase 3, with the majority of RO showing moderate ISI and the majority of ChRCC showing low ISI. Conclusion: The use of caspase-3 could favor the diagnosis of RO in cases where the tumor shows strong and diffuse staining. Further studies on a larger number of cases are needed to confi rm our results.
Keywords
caspase 3; renal oncocytoma; chromophobe renal cell carcinoma; immunohistochemistry
Hrčak ID:
237917
URI
Publication date:
24.4.2020.
Visits: 1.014 *