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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 74 No. 1, 2020.

Professional paper

PROPHYLAXIS OF MIGRAINE – A REVIEW OF LITERATURE

ANA ĆURKOVIĆ KATIĆ ; Split University Hospital Centre, Split, Croatia
MARIO MIHALJ ; Split University Hospital Centre and University of Split, School of Medicine, Department of Neurology, Split, Croatia
ANA REPIĆ BULIČIĆ ; Split University Hospital Centre, Split, Croatia
MARTINA VIDOVIĆ ; Split University Hospital Centre, Split, Croatia
MARINA TITLIĆ ; Split University Hospital Centre and University of Split, School of Medicine, Department of Neurology, Split, Croatia

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Abstract

This literature review is aimed at assessing the possibilities of migraine prophylaxis. The International Headache Society (IHS) recommends performing migraine prophylaxis in patients suffering ≥4 migraine headaches per month, either episodic or chronic. The treatment is deemed successful when the migraine attacks are decreased by ≥50%. Effi ciency has been demonstrated for β-blockers, calcium antagonists, antiepileptics such as topiramate and valproate, as well as gabapentin, pregabalin, fl unarizine and antidepressants. The effi ciency of levetiracetam, cervical myofascial anesthesia, skin electrostimulation and muscular stimulation is still being tested. The effects of botulinum toxin are dubious. There is ongoing research of the possibility of using histamines, closing foramen ovale, acupuncture, supraorbital and vagal nerve stimulation and transcranial magnetic stimulation. Effects of catecholamine, melatonin, contraceptives, ribofl avin, dextromethorphan and melatonin in persisting migraine headaches are being researched as well. Required is an appropriate assessment of the possible effects of probiotics, coenzyme q10 and magnesium in migraine prophylaxis. Clinical researches have shown the use of human monoclonal antibodies erenumab, fremanezumab and galcanezumab to demonstrate a statistically signifi cant effi ciency (≥50%) in migraine prophylaxis, yet requiring further confi rmation in clinical practice.

Keywords

prophylaxis; migraine; efficiency

Hrčak ID:

237934

URI

https://hrcak.srce.hr/237934

Publication date:

24.4.2020.

Article data in other languages: croatian

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