Short communication, Note

https://doi.org/10.2478/v10007-008-0008-1

Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.) Schrad. methanolic fruit extract

SUNIL KUMAR ; Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
DINESH KUMAR ; Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
MANJUSHA ; Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
KAMAL SAROHA ; Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
NIDHAN SINGH ; Department of Botany, Kurukshetra University, Kurukshetra-136119, Haryana, India
BHOODEV VASHISHTA ; Department of Botany, Kurukshetra University, Kurukshetra-136119, Haryana, India

Abstract

Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) is a medicinal plant traditionally used as an abortifacient and to treat constipation, oedema, bacterial infections, cancer and diabetes. Preliminary phytochemical screening of the plant showed the presence of large amounts of phenolics and flavonoids. Subsequent quantification showed the presence of 0.74% phenolics (calculated as gallic acid) and 0.13% flavonoids calculated as catechin equivalents per 100 g of fresh mass. The presence of phenolic compounds prompted us to evaluate its antioxidant activity. In the present study, methanolic fruit extract of C. colocynthis was screened to evaluate its free-radical scavenging ability. The highest antioxidant and free radical scavenging effect of the fruit extract was observed at a concentration of 2500 µg mL1.

Keywords

Citrullus colocynthis (Cucurbitaceae) fruit; methanolic extract; antioxidants; free radical scavenging

Hrčak ID:

22027

URI

https://hrcak.srce.hr/22027

Publication date:

1.6.2008.

Article data in other languages: croatian

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