Short communication, Note
https://doi.org/10.33602/mebm.3.1.9
CASE REPORT: PRE-TRANSPLANT TESTING AND POST-TRANSPLANT MONITORING FOR AN HLA-IMMUNIZED RECIPIENT IN HEART TRANSPLANTATION
Lucija Jukic
; Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia
Biserka Palfi
; Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia
Bosko Skoric
; Department for Cardiovascular Diseases, University Hospital Centre Zagreb, Zagreb, Zagreb, Croatia
Marija Burek Kamenaric
; Tissue Typing Centre, Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia
Abstract
We report the workflow of immunogenetic pre-transplant testing and post-transplant monitoring in the case of a recipient immunized to human leucocyte antigens (HLA) who was waitlisted for heart transplantation. The recipient underwent heart transplantation across preformed HLA class I Donor Specific Antibodies (DSAs) detected by solid phase Luminex screening method but not by complement dependent cytotoxicity (CDC) screening method. The CDC lymphocyte crossmatch, which was performed retrospectively, was a weak positive. Post-transplant DSA monitoring by Luminex method revealed the decrease of HLA-A1, A25 and B57 DSAs with, at the same time, an increase of HLA-B8 DSA, as well as weak transient non-DSA HLA-DP antibodies. This case presents the importance of extensive immunogenetic testing and monitoring for identifying recipients with increased immunological risk for successful heart transplantation.
Keywords
immunogenetics; HLA antibodies; sensitization; DSA monitoring; heart transplantation
Hrčak ID:
238484
URI
Publication date:
1.6.2020.
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