Original scientific paper

https://doi.org/10.2478/acph-2021-0018

Polyethylene oxide matrix tablet swelling evolution: The impact of molecular weight and tablet composition

PETRA DRAKSLER ; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia; Sandoz Development Center, Lek d.d., 1526 Ljubljana, Slovenia
URŠA MIKAC ; Jožef Štefan Institute, 1000 Ljubljana, Slovenia
PETER LAGGNER ; Research Center for Pharmaceutical Engineering (RCPE) GmbH, 8010, Graz, Austria
AMRIT PAUDEL ; Research Center for Pharmaceutical Engineering (RCPE) GmbH, 8010, Graz, Austria; Institute of Process and Particle Engineering, Graz University of Technology, 8010, Graz, Austria
BILJANA JANKOVIĆ ; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia; Sandoz Development Center, Lek d.d., 1526 Ljubljana, Slovenia

Abstract

This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, m/m), taking into consideration excipients and tablet surface area which significantly increased the percolation threshold. Moreover, the robustness of the gel layer in PEO matrix tablets was evaluated by magnetic resonance imaging under various mechanical stresses (no flow, 12 mL min–1, and 64 mL–1 of medium flow). Correlations between the percolation threshold and gel thickness (R2 = 0.86), gel thickness and the erosion coefficient (R2 = 0.96) was detected. Furthermore, small-angle X-ray scattering of the selected PEOs detected differences in polymer molecular complexity at the nanoscale. Finally, the ratio of the heat of coalescence to the heat of fusion has confirmed the PEO molecular mass-dependent percolation threshold.

Keywords

polyethylene oxide; MRI; percolation threshold; SAXS; WAXS

Hrčak ID:

239361

URI

https://hrcak.srce.hr/239361

Publication date:

30.6.2021.

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