Review article

https://doi.org/10.2478/acph-2021-0015

Piperine: Chemical, biological and nanotechnological applications

CHRISTIAN RAFAEL QUIJIA orcid.org/0000-0002-4370-8960 ; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, Brazil
VICTOR HUGO ARAUJO ; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, Brazil
MARLUS CHORILLI orcid.org/0000-0002-6698-0545 ; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, Brazil

Abstract

Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and antiparasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different in vitro and in vivo studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics.

Keywords

absorption; metabolism; pharmacological activity; nanosystems

Hrčak ID:

239362

URI

https://hrcak.srce.hr/239362

Publication date:

30.6.2021.

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