Original scientific paper
https://doi.org/10.3325/cmj.2019.60.99
Neuroprotective and reparative effects of endoplasmic reticulum luminal proteins – mesencephalic astrocytederived neurotrophic factor and cerebral dopamine neurotrophic factor
Katrina Albert
; Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Mikko Airavaara
orcid.org/0000-0002-2026-1609
; Neuroscience Center, University of Helsinki, Helsinki, Finland
Abstract
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic
astrocyte-derived neurotrophic factor (MANF)
are proteins that have received increasing attention in the
last decades. Although they are called neurotrophic factors
they are drastically different from neurotrophic factors in
their expression and physiological actions. They are located
in the lumen of the endoplasmic reticulum (ER) and their
basal secretion from neurons is very low. However their secretion
is stimulated upon ER calcium depletion by chemical
probes such as thapsigargin, a sarco/endoplasmic reticulum
Ca2+-ATPase (SERCA) pump inhibitor. Exogenous
MANF and CDNF possess therapeutic properties in several
neurological disease models, including Parkinson disease
and stroke. Endogenous MANF expression has been
shown to be neuroprotective, as well as administration of
either CDNF or MANF into the extracellular space. In this
review, we focus on their therapeutic effects, regulation of
expression and secretion, comparison of their mechanisms
of action, and their application to the brain parenchyma as
recombinant proteins.
Keywords
Hrčak ID:
239735
URI
Publication date:
15.4.2019.
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