Professional paper

https://doi.org/10.15836/ccar2020.229

Vascular Health and Cardiovascular Outcomes: Focus on Perindopril and its Combinations

Tina Kuhar ; Krka, d. d., Novo mesto, Slovenia
Alenka Kmecl ; Krka, d. d., Novo mesto, Slovenia
Mateja Grošelj ; Krka, d. d., Novo mesto, Slovenia
Breda Barbič-Žagar orcid.org/0000-0002-1173-7361 ; Krka, d. d., Novo mesto, Slovenia

Abstract

Endothelial dysfunction is the earliest vascular abnormality and it is involved in all stage of the cardiovascular continuum. Antihypertensive compounds should ideally have additional endothelial protective properties beyond their ability to reduce blood pressure. Among angiotensinconverting enzyme inhibitors, perindopril appears to have the greatest endothelial protective effects. Amlodipine is well known for its atheroprotective effect. Clinical evidence has shown that perindopril and amlodipine could individually interrupt and slow the progression of cardiovascular disease with long-term beneficial effects of treatment on mortality. The effect is enhanced and broadened if both agents are used together. Early prescription of perindopril and amlodipine appears to be important, as most of the treatment benefits of both agents occur in the early or middle stages of the cardiovascular continuum. Clinical evidence also supports the beneficial effect on the vascular endothelium offered by the triple combination of perindopril and amlodipine with indapamide.

Keywords

perindopril; amlodipine; endothelial dysfunction; cardiovascular continuum

Hrčak ID:

240376

URI

https://hrcak.srce.hr/240376

Publication date:

1.7.2020.

Article data in other languages: croatian

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