Original scientific paper

https://doi.org/10.37797/ig.39.3.1

Changes in the stage of fibrosis and steatosis in patients with chronic hepatitis C virus treated with direct-acting antiviral drugs who achieved sustained virological response

Leona Radmanić orcid.org/0000-0001-9362-7213 ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb
Neven Papić ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb; School of Medicine, University of Zagreb
Ivan Kurelac ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb
Davorka Dušek ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb; School of Medicine, University of Zagreb
Snježana Židovec Lepej ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb
Adriana Vince ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb; School of Medicine, University of Zagreb

Abstract

Hepatitis C is the leading cause of chronic liver disease, hepatocellular carcinoma and an important indication for liver transplantation. The main objective of the treatment is to achieve a sustained virological response defined as a negative HCV RNA 12 weeks after completion of therapy (SVR). Direct-acting antivirals have been developed to treat chronic HCV infection. They have resulted in increased SVR rates, shorter and simpler treatment regimens, and minimal adverse effects. The aim of this study was to analyze the change in the stage of fibrosis (F1-F4) and steatosis (S0-S3) using transient elastography in treating naive patients with chronic hepatitis C (n = 205) who achieved a sustained virological response and were treated exclusively with directly acting antiviral drugs (DAA).

Keywords

chronic hepatitis C; fibrosis; steatosis; sustained virological response; direct-acting antiviral drugs

Hrčak ID:

240584

URI

https://hrcak.srce.hr/240584

Publication date:

5.7.2020.

Article data in other languages: croatian

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