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Acta clinica Croatica, Vol. 59. No. 1., 2020.

Original scientific paper

https://doi.org/10.20471/acc.2020.59.01.03

Serum Bilirubin Correlates with Serum Adipokines in Normal Weight and Overweight Asymptomatic Adults

Ana Petelin ; Faculty of Health Sciences, University of Primorska, Izola, Slovenia
Mihaela Jurdana ; Faculty of Health Sciences, University of Primorska, Izola, Slovenia
Zala Jenko Pražnikar ; Faculty of Health Sciences, University of Primorska, Izola, Slovenia
Lovro Žiberna orcid id orcid.org/0000-0002-2840-5208 ; Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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Abstract

Overweight and obesity are considered as chronic low-grade inflammation accompanied by imbalanced production of adipokines. The aim of this study was to elucidate the relationship between serum bilirubin, which is an endogenous antioxidant with anti-inflammatory
activity, and pro- and anti-inflammatory serum adipokines in asymptomatic normal weight and overweight individuals. Healthy men and women aged 25-49 participated in this cross-sectional study. All participants underwent fasting serological measurements of adipokines, interleukin-6, tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), total and direct serum bilirubin, and other biochemical parameters. Participants were divided into normal weight and overweight groups. We found a significant negative association between total bilirubin and CRP, TNF-α, visfatin and resistin values, and a significant positive association between total bilirubin and adiponectin values in both normal weight and overweight groups. Importantly, after adjusting for body mass index, we also found a significant negative association between total serum bilirubin levels and both visfatin and
CRP serum levels. Moreover, visfatin, resistin and CRP were predictors of the total serum bilirubin levels.

Keywords

Adipokines; Bilirubin; C-reactive protein; Overweight; Obesity; Cross-sectional studies

Hrčak ID:

242192

URI

https://hrcak.srce.hr/242192

Publication date:

1.3.2020.

Article data in other languages: croatian

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