Review article

https://doi.org/10.2478/acph-2021-0021

Cannabigerol and cannabichromene in Cannabis sativa L.

MARJETA ZAGOŽEN orcid.org/0000-0002-5634-6196 ; Department for Plants, Soil, and Environment, Slovenian Institute of Hop Research and Brewing 3310 Zalec, Slovenia
ANDREJA ČERENAK ; Department for Plants, Soil, and Environment, Slovenian Institute of Hop Research and Brewing 3310 Zalec, Slovenia
SAMO KREFT ; The Chair of Pharmaceutical Biology, University of Ljubljana, Faculty of Pharmacy, Ljubljana Slovenia

Abstract

In addition to delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), other phytocannabinoids, such as cannabigerol (CBG) and cannabichromene (CBC), also have beneficial effects on human health. A high content of CBG is found in plants with the B0 genotype, whereas CBC is independent of the allelic chemotype locus B. In basic research models such as mice or rats, CBG has demonstrated anticancer properties, particularly against breast cancer. CBG has shown anti-inflammatory effects on murine colitis and on inflammatory bowel disease as well as stimulatory effects on the feeding behaviors of mice. It has also exhibited inhibition of aldose reductase, which is known to cause an accumulation of sorbitol and increase glucose levels in the blood, which may lead to diabetes. Cannabinoid CBC has also shown anti-inflammatory effects and reduced hypermobility in the gut and has displayed potential in vitro effect on adult neural stem progenitor cells. CBC also exerts modest analgesic properties in rodents, as well as anti-fungal, anti-bacterial, pro-apoptotic, and anti-proliferative effects in tumor cells.

Keywords

cannabinoids; chemotype; health effects; hemp; receptors

Hrčak ID:

242229

URI

https://hrcak.srce.hr/242229

Publication date:

30.9.2021.

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