Review article

LIPID PEROXIDATION - CAUSES AND CONSEQUENCES

Leo Štefan ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Tina Tepšić ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Tina Zavidić ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Marta Urukalo ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Dalibor Tota ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Robert Domitrović ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia

Abstract

ABSTRACT
Occasionally, under normal biological conditions, oxygen does manage to steal away electrons from other molecules by nonenzymatic autoxidations, which results in the free radical formation. Polyunsaturated fatty acids frequently serves as the target for generated free radicals, inducing lipid peroxidation. Intracellular and extracelular antioxidants attenuate oxidative damage of lipid
molecules, primarily PUFA, but also other molecules. The most efficient way to eliminate undesirable toxic species is by means of enzyme catalysis. Families of antioxidant enzymes have evolved for this purpose, including superoxide dismutases (SOD) for the elimination of the superoxide radical, and catalases (CAT) and glutathione peroxidases (GPx) for the elimination of hydrogen peroxide and organic peroxides. Lipid damage could be determined by measuring the amount of malondialdehyde (MDA), 4-hydroxynonenal (HNE), isoprostanes and other products of lipid peroksidation. Increased lipid peroxidation increase the risk of atherogenesis and other inflammatory diseases.

Keywords

reactive oxygen species; antioxidants; lipid peroxidation; atherosclerosis

Hrčak ID:

22556

URI

https://hrcak.srce.hr/22556

Publication date:

25.6.2007.

Article data in other languages: croatian

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