Review article

LIVER BIOPSY IN HEPATITIS C INFECTION

Dražen Kovač ; Department of patology, School of medicine, University of Rijeka, Rijeka, Croatia

Abstract

SUMMARY
Liver needle biopsy is the best diagnostic procedure to estimate a profound of liver damage, not only in Hepatitis, then in the other liver diseases. Specimen provided by liver needle biopsy is used generally for patohistological analysis, but also could be used for electron microscopy and molecular analysis. Specimen has to be 1,5 cm long and 0,2 cm wide at least and must contain
6 whole portal areas for assesing HAI (histology activity index). HAI is a numerical score for evaluation the grade of liver damage. In 1995, Ishak and colleagues were introduced a numerical score which used a terms grading and staging. Grading means the degree of liver damage (piecemeal necrosis, confluent ang bridging necrosis, focal necrosis and apoptosis, portal inflammation), staging means architectural changes, fibrosis and cirrhosis. Total score is a guideline for a clinician to choose an exact therapeutic protocol.

Keywords

liver biopsy; grading; staging; liver damage; fibrosis

Hrčak ID:

22566

URI

https://hrcak.srce.hr/22566

Publication date:

25.6.2007.

Article data in other languages: croatian

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