Original scientific paper
https://doi.org/10.5281/zenodo.4059842
Microencapsulation of dronedarone hydrochloride by spray drying
Matija Gretić
; Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Gordana Matijašić
; Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Juraj Petanjek
; Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Abstract
Microencapsulation is a method often used in various industries and one of the many advantages is that con-trolled release of the active ingredient can be achieved. The aim of this study was to prepare microcapsules by spray drying by changing the process conditions and ratios of the used components, polymer excipient poly(vinyl alcohol) and active ingredient dronedarone hydrochloride. Dosage forms of poly(vinyl alcohol) and dronedarone hydrochloride were prepared in 1:1, 2:1 and 3:1 weight ratios and the solutions were dried in a laboratory spray dryer at four different atomization flowrates. The morphology of the obtained microcapsules was examined using a scanning electron microscope (SEM). The release kinetics of the active ingredient from the microcapsules were examined by in vitro laboratory testing and the resulting release profiles were described using the Weibull model. The results showed that the change of weight ratio has influence on the morphology of microcapsules, the effi-ciency of microencapsulation and drug release.
Keywords
Hrčak ID:
244396
URI
Publication date:
3.8.2020.
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