Review article
SERUM BIOMARKERS OF COLLAGEN TYPE I AND TYPE III TURNOVER IN HEART FAILURE – THE NEED FOR REAPPRAISAL
ASPARUH NIKOLOV
; Cardiovascular Research Working Group, Institute for Scientific Research, Medical University of Pleven, Pleven, Bulgaria
MARIA TZEKOVA
; University Hospital Pleven, Second Clinic of Cardiology, Department of Propaedeutics in Internal Medicine, Medical University of Pleven, Pleven, Bulgaria
KONSTANTIN KOSTOV
; University Hospital Pleven, Second Clinic of Cardiology, Department of Propaedeutics in Internal Medicine, Medical University of Pleven, Pleven, Bulgaria
Abstract
Cardiac extracellular matrix is a complex structure presented by a network of fi brillar collagen, fi bronectin, laminin, fi brillin, elastin, glycoproteins and proteoglycans. Myocardial fi brillar collagens (collagen type I and type III) are the main proteins responsible for the structural integrity of the bordering cardiomyocytes. Increased accumulation of fi brillar collagen leading to fi brosis has been reported in pathological cardiovascular conditions like heart failure. Amino-terminal and carboxyterminal propeptides of collagen type I and III are the two major collagen types playing a central role in this process. Derived products from their turnover have been determined in serum of patients with heart failure. Collagen type I and III propeptides refl ect collagen synthesis and degradation. Their use as biomarkers with prognostic or diagnostic aim is an area of intensive studies. This review article summarizes the actual available literature data on serum markers of collagen type I and III turnover in heart failure and discusses their potential as circulating indicators of cardiac fi brosis. The use of collagen type I and III peptides for diagnosis, prognosis and monitoring of heart failure is thoroughly discussed too.
Keywords
collagen; biomarkers; heart failure; myocardial fibrosis
Hrčak ID:
244546
URI
Publication date:
6.10.2020.
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