Original scientific paper

https://doi.org/10.2478/v10007-008-0009-0

Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits

AMANY HASSAN MOHAMED EL-SHAZLY ; Ocular Pharmacology Departments, Research Institute of Ophthalmology, Giza, Egypt
AMAL AHMAD EL-GOHARY ; Ocular Physiology Departments, Research Institute of Ophthalmology, Giza, Egypt
LAILA HASSAN MOHAMED EL-SHAZLY ; Ocular and Pathology Department, Memorial Institute of Ophthalmology, Giza, Egypt
GHADA GHANEM EL-HOSSARY ; Ocular Pharmacology Departments, Research Institute of Ophthalmology, Giza, Egypt

Abstract

The purpose of this study was to compare the topical anti-inflammatory effects of the nonselective cyclooxygenase (COX) inhibitor, ketorolac, with the selective COX-2 inhibitor, nimesulide, in an animal model of dry eye in albino rabbits. All animals were examined by the Schirmer test, tear break-up time (TBUT) and fluorescein corneal staining test. Dry eye model showed significant reduction in tear volume, TBUT, corneal staining and histopathological signs of dryness and inflammation. On treating dry eye model with nimesulide 0.1% eye drops and ketorolac 0.5% eye drops, there were improvements in Schirmer test values, TBUT and fluorescein corneal staining and histopathologically reduced inflammatory reaction, with signs of healing and regeneration. Both nimesulide and ketorolac ameliorate atropine sulphate induced dry eye in albino rabbits. The use of selective COX-2 inhibitor, nimesulide, is preferred to avoid local and systemic side effects which may occur with the use of the nonselective COX inhibitor, ketorolac.

Keywords

dry eye model; rabbit; atropine sulphate; Schirmer test I; nimesulide; ketorolac

Hrčak ID:

22595

URI

https://hrcak.srce.hr/22595

Publication date:

1.6.2008.

Article data in other languages: croatian

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