Original scientific paper

https://doi.org/10.24099/vet.arhiv.0675

Anti-inflammatory and antioxidant effects of turmeric extracts in rat adjuvant arthritis

Rūta Bradūnaitė orcid.org/0000-0002-8872-1771 ; Department of Biomodels, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Laima Leonavičienė orcid.org/0000-0003-1566-0741 ; Department of Biomodels, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Laimis Akramas ; Pharmaceutical Company “Aksada”, Kaunas, Lithuania
Miglė Leonavičiūtė-Klimantavičienė orcid.org/0000-0001-8994-6078 ; Vilnius University Faculty of Medicine, Vilnius, Lithuania
Audrius Vasiliauskas ; Department of Biomodels, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Irena Dumalakienė ; Immunology Department, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Irena Jonauskienė ; Department of Biomodels, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Justinas Baleišis ; Department of Biomodels, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Zygmunt Mackiewicz ; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

Abstract

The aim of the study was to evaluate the antioxidant, immunomodulatory and anti-arthritic effects of turmeric extracts (Standard and CurQfen) on rat adjuvant arthritis. The impact of the treatment was investigated on pro- and antioxidant status, serum interleukins IL-17 and IL-1β, blood indices, joint swelling, and histological changes in the joints, liver and body weight. Both turmeric extracts improved blood indices, decreased the level of pro-inflammatory cytokines, and enhanced antioxidant level. Both extracts diminished swelling and normalized histological structure in soft periarticular tissues, synovial membrane and hyaline cartilage. No negative effect on the liver was observed. CurQfen was more effective than Standard extract. The strong antioxidative, anti-inflammatory and immunomodulatory effects of the turmeric extracts suggest their usefulness in the treatment of autoimmune arthritis as monotherapy or in combination with traditional anti-arthritic drugs.

Keywords

turmeric extracts; antioxidant activity; adjuvant arthritis; rats

Hrčak ID:

245191

URI

https://hrcak.srce.hr/245191

Publication date:

22.10.2020.

Article data in other languages: croatian

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