Original scientific paper
URINARY IODINE CONCENTRATION: PREDICTOR OF BIRTH WEIGHT OR BIOMARKER FOR ASSESSING THE IODINE STATUS IN HEALTHY PREGNANT WOMEN, ONLY?
MAJA AVRAMOVSKA
orcid.org/0000-0003-1129-1205
; Clinical Hospital “Dr Trifun Panovski” – Bitola, Department of Obstetrics and Gynecology, Bitola, North Macedonia
BORISLAV KARANFILSKI
; Institute of Pathophysiology and Nuclear Medicine, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
GORAN DIMITROV
; University Clinic of Obstetrics and Gynecology, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
GLIGOR TOFOSKI
; University Clinic of Obstetrics and Gynecology, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
ELENA DZIKOVA
; University Clinic of Obstetrics and Gynecology, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
ANA DANEVA MARKOVA
; University Clinic of Obstetrics and Gynecology, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
MARIJA HADZI-LEGA
; Danat Al Emarat Hospital for Women and Children, Abu Dhabi, United Arab Emirates
KOSTA SOTIROSKI
; Faculty of Economics – Prilep, Department of Statistics, St. Clement of Ohrid University – Bitola, North Macedonia
OLIVIJA VASKOVA
; Institute of Pathophysiology and Nuclear Medicine, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
ALEKSANDAR SIKOLE
; University Clinic of Nephrology, Medical Faculty -Skopje, Ss. Cyril and Methodius University, Skopje, North Macedonia
Abstract
Introduction: This study determined urine iodine concentration (UIC) during gestation, assessed the maternal iodine nutrition status and correlated it with gestational age at birth (GAB) and birth weight (BW).The measurement of UIC provides the best single measurement of the iodine nutritional status in population. Objective: Determination of UIC in pregnant women in North Macedonia. Methods: This prospective study assessed the iodine nutrition status during the course of pregnancy with reference of median UIC among 364 healthy pregnant women in different gestational age (in trimester and 5-week intervals). Results: The overall and the 1st to the 3rd trimester median UIC were: 183.7, 207, 189.75 and 169.28 [μg/L], respectively. The median UIC (μg/L) results according to 5-week interval in advancing gestation were: 232.34, 200.13, 152.81, 194.39, 181.28, 160.28, 169.41 and 175.24, respectively. We detected 5.22% (19/364) and 74.72% (272/364) with
the median UIC < 50 μg/L and UIC ≥ 100 μg/L, respectively. In multiple regression, the median UIC (β = 0.0000767, P = 0.929) had no statistically signifi cant prediction to the GAB. Disease prevalence results for mean UIC in detecting BW had no statistical signifi cance: area under curve (AUC) = 0.521, z-statistic (0.340), sensitivity (45.83%), specifi city (66.27%), predictive (6.59%) and P value (0.734). Conclusion: Iodine status of pregnant women in our study is generally suffi cient by World Health Organization recommendations. The median UIC in each trimester and 5-week interval has statistically insignifi cant decrease in accordance to the advancing gestation. The median UIC has no signifi cance in predicting GAB and BW.
Keywords
pregnancy; urinary iodine concentratio; iodine nutritional status; birth weight; gestational age at birth; thyroid metabolism
Hrčak ID:
245735
URI
Publication date:
6.11.2020.
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