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NEFROPATIJA POVEZANA S VIRUSOM JOHN CUNNINGHAM U PRIMATELJA TRANSPLANTATA BUBREGA
MARKO BANIĆ
; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation; University of Zagreb, School of Medicine, Zagreb, Croatia
MARIJANA ĆORIĆ
; Zagreb University Hospital Centre, Department of Pathology; University of Zagreb, School of Medicine, Zagreb, Croatia
VESNA FURIĆ-ČUNKO
; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
MISLAV MOKOS
; University of Zagreb, School of Medicine, Zagreb, Croatia
IVANA JURIĆ
; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
NIKOLINA BAŠIĆ-JUKIĆ
orcid.org/0000-0002-0221-2758
; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation; University of Zagreb, School of Medicine, Zagreb, Croatia
Abstract
Dok je John Cunningham (JC) virus dobro poznati uzročnik progresivne multifokalne encefalopatije, dosad je opisan kao uzročnik nefropatije u tek nekoliko slučajeva. Prikazujemo bolesnika s transplantiranim bubregom koji se prezentirao proteinurijom i porastom serumskog kreatinina. Biopsijom presatka je dokazana poliomavirusna nefropatija. Uporabom lančane reakcije polimeraze BK virus i JC virus su bili negativni u krvi, u mokraći je BK virus bio negativan, a JC virus pozitivan, dok je iz bioptata dokazano više od 106 kopija DNA JC virusa, čime smo potvrdili dijagnozu nefropatije presatka uzrokovane JV virusom. Bolesnik je liječen intravenskim imunoglobulinima uz smanjivanje intenziteta imunosupresije. Ovaj bolesnik potvrđuje da JC virus može uzrokovati značajne promjene u bubrežnom presatku i da ga treba uključiti u diferencijalnu dijagnozu pogoršanja funkcije presatka.
Keywords
imunosupresija; transplantacija bubrega; JC virus; JC virusna nefropatija
Hrčak ID:
245739
URI
Publication date:
6.11.2020.
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