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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 74 No. 3, 2020.

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JOHN CUNNINGHAM VIRUS-ASSOCIATED NEPHROPATHY IN A KIDNEY TRANSPLANT RECIPIENT

MARKO BANIĆ ; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation; University of Zagreb, School of Medicine, Zagreb, Croatia
MARIJANA ĆORIĆ ; Zagreb University Hospital Centre, Department of Pathology; University of Zagreb, School of Medicine, Zagreb, Croatia
VESNA FURIĆ-ČUNKO ; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
MISLAV MOKOS ; University of Zagreb, School of Medicine, Zagreb, Croatia
IVANA JURIĆ ; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
NIKOLINA BAŠIĆ-JUKIĆ orcid id orcid.org/0000-0002-0221-2758 ; Zagreb University Hospital Centre, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation; University of Zagreb, School of Medicine, Zagreb, Croatia

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Abstract

John Cunningham (JC) virus is a well-known cause of progressive multifocal encephalopathy. Only a few cases of polyomavirus-associated nephropathy due to JC virus have been reported so far. We report one such case in a kidney transplant recipient who presented with proteinuria and increased serum creatinine. Allograft biopsy revealed polyoma virus-associated nephropathy. Real-time polymerase chain reaction revealed negative result for BK and JC virus in the blood, negative for BK virus and positive for JC virus in the urine, and fi nally, when performed on the biopsy sample it detected more than 106 copies of JC virus DNA, which allowed us to establish JC virus-associated nephropathy as a defi nitive diagnosis. The patient was treated with intravenous immunoglobulins and reduction of immunosuppression. Serum creatinine returned to initial levels with decrease of proteinuria. This case documents that JC virus may cause signifi cant changes in renal allograft and should be included in the differential diagnosis of allograft dysfunction.

Keywords

immunosuppression; kidney transplantation; JC virus; JC virus nephropathy

Hrčak ID:

245739

URI

https://hrcak.srce.hr/245739

Publication date:

6.11.2020.

Article data in other languages: croatian

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