Original scientific paper

Synthesis of Aminoalkylglyoxal Derivatives III. Aminoalkylglyoxal Derivatives of α-Aminobutyric Acid and Valine*

K. Balenović ; Chemical Laboratory, Faculty of Science, University of Zagreb, Strossmayerov trg 14, Zagreb, Croatia, Yugoslavia, and Institute »Ruder Boskovic«, Department of Biochemistry
V. Škarić ; Chemical Laboratory, Faculty of Science, University of Zagreb, Strossmayerov trg 14, Zagreb, Croatia, Yugoslavia, and Institute »Ruder Boskovic«, Department of Biochemistry
D. Dvornik ; Chemical Laboratory, Faculty of Science, University of Zagreb, Strossmayerov trg 14, Zagreb, Croatia, Yugoslavia, and Institute »Ruder Boskovic«, Department of Biochemistry

Abstract

Starting from DL-a-aminobutyric acid and DL-v a line the corresponding aminoalkylglyoxals VIIa and VIIb were prepared by Krohnke's method , through the reaction stages II-VII. Further, a description is given of the pireparation of DL-1-acetoxy-3-phthalim idorpent an- 2-one, and of the conversion of the glyoxal VIIa into the 1, 1-diethylacetal VIIIa, the hydroxyacetal IXa, and the a-glycol Xa, which are useful intermed iates for the synthesis of compounds of the type I. The aldehyde group of these glyoxals readily reacts with N,N-diphe n yl-1,2-dia minoethane, affording condensation products XI. Quinoxaline and bisethylenemerc aptal derivatives of the glyoxals VII were also prepared. Improved pireparations are described for DL- a - amino butyric acid and the corresponding phthalimido derivative.

Keywords

Hrčak ID:

246711

URI

https://hrcak.srce.hr/246711

Publication date:

6.2.1957.

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